Cutting It Out: ENaC Processing in the Human Nephron
نویسندگان
چکیده
منابع مشابه
Cutting it out: ENaC processing in the human nephron.
Studies over the past decade have shed light on how proteases activate the epithelial sodium channel (ENaC). Two ENaC subunits (a and g) have short stretches of embedded amino acid residues that inhibit the channel. Following proteasedependent cleavage of these subunits at sites flanking these inhibitory tracks, fragments are released and channels are activated. The serine protease furin is exp...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2014
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2014060618